News & Events

NEWS

Our paper on multimodal mapping the microscale dynamics of epileptic networks is accepted in Communications Biology

Congratulations to the first co-authors Nicki Driscoll and Richard Rosch from the Dani Bassett Lab for the acceptance of their paper  “Multimodal in vivo recording using transparent graphene microelectrodes illuminates spatiotemporal seizure dynamics at the microscale” in Communications Biology. This study proposes a new framework to combine microECoG and calcium imaging datasets collected through transparent microelectrode arrays to identify microscale dynamics of epilepsy in mouse models. Here the link to the online version of the paper.

Welcome new PhD students

Yuzhang Chen (Neuroscience), Sneha Shankar, and George Menztelopoulos (Bioengineering) join the lab for their PhD studies. Welcome!

Dr. Vitale receives the Linda Pechenik Montague Investigator Award

Dr. Vitale has received the Linda Pechenik Montague Investigator Award.
This prestigious award was created by the philanthropist Linda Pechenik Montague to recognize the most promising research faculty at the Perelman School of Medicine. In addition to the prestigious recognition, the award will provide $100,000 to support the research work of Dr. Vitale.
Thanks to Linda Pechenik Montague and to the Perelman School of Medicine for this honor.

Meet the Vitale Lab at BMES 2019

We are getting ready for BMES 2019, which this year will be hosted here in Philadelphia. This year there will be a great representation from the Vitale lab, with 3 oral and 2 poster presentations. 
Here the details of our presentations:

  • Thursday Oct. 17, 2.15p. Room 120C Nicolette Driscoll will present her talk: “Ti3C2 MXene for Dry EEG Electrodes” (Authors: N. Driscoll, B. Erickson, B. Murphy, N. Apollo, J. Medaglia, F. Vitale)
  • Friday Oct. 18, Room 115C Teddy Wang will present his talk: “Flexible, Transparent micro-LED Arrays for Optogenetic Stimulation of Living Electrodes”, (Authors: T. Wang, N. Driscoll, O. Adewole, M. Serruya, K. Cullen, F. Vitale.)
  • Friday Oct. 18 Matthew Zwimpfer and Kayla Prezelski will present their poster: “MINT: A Multipoint INjection Technology For Intracerebral Gene Transfer” (Authors: M. Zwimpfer, K. Prezelski, M. Kaiser, T. Lucas, P. Gonzalez-Alegre, F. Vitale)
  • Saturday Oct. 19, 8.15a Room 120C Brendan Murphy will present his talk: “A Ti3C2 MXene-Based Array For High-Density Surface Electromyography “ (Authors: B. Murphy, N. Driscoll, N. Apollo, A. Richardson, P. Mulcahey, G. Robbins, T. Dillingham, F. Vitale)
  • Saturday Oct. 19 Gary Eberly will present her poster: “Transparent MXene MicroECoG Electrodes For Multi-Modal Seizure Monitoring”. (Authors: G. Eberly, N. Driscoll, B. Murphy, F. Vitale. )

Come and meet us at BMES!

Dr. Vitale receives the K12 Career Development Award

Dr. Vitale has received the Interdisciplinary Rehabilitation Engineering Career Development Award (IREK12). This award will support her on wearable EMG sensors to study fundamental mechanisms involved in neuromuscular disorders and support targeted rehabilitation strategies.

The Interdisciplinary Rehabilitation Engineering Research Career Development Program (IREK12) in Movement and Rehabilitation Sciences (MRS) recruits and trains scholars with engineering and other quantitative backgrounds to become successful rehabilitation scientists in basic, translational and/or clinical research. To read more about the program: https://irek12.org

Welcome summer students!

We are very excited to welcome to the 6 new students who will be joining the Vitale Lab team for the summer.

Placid Unegbu has just completed his Master’s degree in Bioengineering at Penn and will be working on closed-loop control of electrodes for neural recording and optogentic stimulation. Gari Eberly (rising junior in Biomedical Engineering Bucknell University) and Tessa Posey (rising senior in Bimedical Engineering at the University of South Carolina) from the Singh Center REU program, Nancy Rodriguez-Perez (rising junior in Civil Engineering at ASU) from the REU SUNFEST Program, and Quincy Hendricks (rising sophomore in Bioengineering at Penn) will be working on microfabrication and characterization of our neural electrodes. Campbell Parker (rising junior in in Bioengineering at Penn) will be working on optimizing our film casting setup.

This will be a busy and super productive summer in the Vitale Lab!

Our paper on MXene neuroelectronics is accepted in ACS Nano!

Nicki’s paper on high-resolution neural electrodes based on MXene has been accepted for publication in ACS Nano. The paper describes the first example of neural interfaces from MXene, a 2D nanomaterial recently discovered by Prof. Gogotsi and his team at Drexel. Specifically, we show a novel microfabrication process to fabricate neural recording electrodes from MXene and we extensively characterize them in vitro and in vivoCompared to conventional electrode materials, like metals, MXene neural electrodes have significant less impedance which translates in higher signal-to-noise ratio. Furthermore, they can detect neural spiking activity that is “invisible” on the higher impedance electrodes. In the paper, we also show that our MXene-based devices are flexible, that they can easily conform to the curved surface of the brain, and that are compatible to neuronal growth and proliferation in vitro.

Congratulations Nicki!

To read more: https://pubs.acs.org/doi/10.1021/acsnano.8b06014

Dr. Flavia Vitale awarded McCabe Fellow Award

Dr. Flavia Vitale has been awarded the McCabe Fellow Award on July 13, 2018.The McCabe awards were established in 1969 by a generous gift from Mr. Thomas B. McCabe and Mrs. Jeannette E. Laws McCabe to the Perelman School of Medicine (PSOM). The purpose of this gift is to support junior faculty who initiate fresh and innovative biomedical and surgical research projects.

For more information: http://www.med.upenn.edu/evdresearch/mccabefundawardprogram.html

Nick Apollo, PhD joins the CNT

 

Nicholas ApolloDr. Nick Apollo is the newest addition to the CNT working alongside Drs. Flavia Vitale and Brian Litt after being awarded a trainee position in the Neuroengineering and Medicine T32 Training Grant. He is working to develop conformable biosensors capable of simultaneously monitoring neurotransmitter concentration and electrophysiological activity in real time. He will also investigate the use of 2D titanium carbide nanomaterials in neural interfacing and biosensing.

He has training in biomedical engineering (BSE ’11, University of Pittsburgh) and materials science (PhD ’17, University of Melbourne). Prior to beginning postdoctoral training at the University of Pennsylvania, he was working as a fabrication scientist at the University of Melbourne in Australia focused on building carbon-based medical devices. His research interests include carbon materials (graphene, diamond, and carbon nanotubes), brain-machine interfacing, medical device integration and packaging, and biosensing.

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